Aethlon Medical’s Exosome Sciences Announces the Publication of Preliminary Findings of a Blood Test to Detect Chronic Traumatic Encephalopathy (CTE) During Life


Aethlon Medical’s Exosome Sciences Announces the Publication of Preliminary Findings of a Blood Test to Detect Chronic Traumatic Encephalopathy (CTE) During Life

 

 PRNewswire $AEMD

Exosome Sciences, Inc., in collaboration with majority shareholder Aethlon Medical, Inc. (AEMD) and investigators at Boston University and the University of Washington, announced today the published preliminary results of possibly the first blood test to detect the neurodegenerative disease, Chronic Traumatic Encephalopathy (CTE) during life. An early online version of these findings has been published in the Journal of Alzheimer’s Disease. CTE is associated with exposure to repetitive head impacts, such as those experienced by American football players, and can only be diagnosed post-mortem at this time.

 

The researchers developed a method of measuring plasma exosomal tau, also referred to as a TauSome™.  Exosomes are very small vesicles that are released from all types of cells throughout the body, including brain cells.  They can be isolated in all body fluids, including plasma, a component of blood. Exosomes carry within them the proteins from their cells of origin.  Because exosomes can cross the blood-brain-barrier (a selective barrier that separates the circulating blood from the brain’s extracellular fluid), they can provide a unique method of measuring certain aspects of the contents of brain cells through a blood test.  That is, if the brain-derived exosomes can be isolated in plasma and then be stained for specific proteins found in the brain cells, researchers can potentially measure brain proteins through a blood test.  That was the goal of this preliminary study.

The ability to diagnose CTE during life will allow researchers to better determine its incidence and prevalence, to examine risk factors to understand why some people get CTE and others do not, and to begin clinical trials of methods aimed at treating and ultimately preventing the disease.  Because CTE is very similar to Alzheimer’s disease and other related neurodegenerative diseases, the results of this new study may eventually lead to improved methods of detecting these other causes of dementia.

For this study, researchers examined 78 former National Football League (NFL) players and a control group of 17 former non-contact sport athletes. All subjects were participants in a larger project that was funded by a grant from the National Institutes of Health to develop a variety of biomarkers for CTE conducted at Boston University School of Medicine. Results demonstrated that plasma exosomal tau was significantly elevated in the group of former NFL players compared to the control group and that, within the former NFL player group, the number of tau-positive plasma exosomes was significantly correlated with performance on standardized tests of memory and psychomotor speed; the higher the TauSome level, the worse the performance.

“We are extremely pleased that our initial study data has been published and we appreciate forthcoming opportunities to further advance our TauSome™ biomarker as a non-invasive solution to detect and monitor CTE in living individuals,” stated Jim Joyce, Founder of Exosome Sciences and Chairman and CEO of Aethlon Medical.

Access to the on-line version of the publication can be accessed through: http://tinyurl.com/zvyd23h
The researchers note that this is a preliminary study and is the first of several steps necessary to validate a TauSome test to detect CTE and potentially monitor its progression. The study was limited by a relatively small sample size and the lack of any additional possible biomarker of CTE.

Furthermore, because of the methods used, the researchers cannot be completely confident that the exosomes that were isolated definitely came from the brain or that the specific form of tau that was measured is the same form of abnormal tau found in CTE.  A series of future TauSome studies are already planned, including collaboration with a multisite, 7-year $16 million grant recently awarded to Stern and colleagues by the NIH to develop methods of diagnosing CTE during life.

About Exosome Sciences

Exosome Sciences, Inc., in collaboration with majority shareholder Aethlon Medical (AEMD), is focused on discovering exosomal biomarkers to diagnose and monitor Alzheimer’s disease (AD), Chronic Traumatic Encephalopathy (CTE) and other neurological disorders.  Our TauSome™ biomarker (also referred to as exosomal tau) is being studied as the basis for a blood-based test to identify CTE through the DETECT Study being conducted by the Boston University CTE Center.  TauSome™ detection and the use of a TauSome™ biomarker to identify and monitor CTE and other neurological disorders are protected by multiple patent applications.

Visit www.exosomesciences.com for additional details.

About Aethlon Medical, Inc.
Aethlon Medical (AEMD) creates affinity biofiltration devices to treat life-threatening diseases. The Aethlon Hemopurifier® is a leading broad-spectrum treatment countermeasure against infectious viral pathogens.  The device, which has been successfully administered to individuals infected with HIV, Hepatitis C (HCV) and Ebola virus, is currently the subject of FDA approved clinical studies. Aethlon is also studying the potential use of the Hemopurifier® to address exosomes secreted by tumors to promote the spread of metastasis and suppress the immune system of cancer patients.  The Company provides government contracting services to the Defense Advanced Research Projects Agency (DARPA) related to the development of a biofiltration device to treat sepsis and maintains majority ownership of Exosome Sciences, Inc., which is focused on the discovery of exosomal biomarkers to diagnose and monitor Chronic Traumatic Encephalopathy (CTE) and other neurological disorders.
 Additional information can be found online at www.AethlonMedical.com or you can connect with us on Twitter, LinkedIn, Facebook and Google+.

Texas Entrepreneur, Charles Smith, Joins Rocky Mountain High Brands, Inc. (RMHB) Board of Directors


Texas Entrepreneur, Charles Smith, Joins Rocky Mountain High Brands, Inc. (RMHB) Board of Directors

DALLAS, Feb. 23, 2016 (GLOBE NEWSWIRE) — Rocky Mountain High Brands, Inc. (OTC PINK: RMHB) announced today that Texas Businessman and Entrepreneur, Charles ‘Chuck’ Smith, has joined the Rocky Mountain High Brands Board of Directors.
Mr. Smith is a real estate investor and has been an active participant in real estate investment properties for almost 35 years. Throughout his career, he has been involved in the negotiation, acquisition, renovation, refinance and sale of commercial real estate investments in several major cities in Texas. Mr. Smith has served as the Managing Partner in many areas of the investment vehicles which he has taken to market.  He graduated with honors from the University of Texas with a Bachelor’s Degree in Economics and Finance.
Jerry Grisaffi, Founder of Rocky Mountain High Brands, stated, “Chuck has earned tremendous respect from business partners, brokerage houses and banking industries from his expertise in such a broad spectrum of financial vehicles. His long term record of transactions yielding double digit returns has attracted investor clients from diverse professional backgrounds, including attorneys, entertainers, company executives, and many others. Chuck fills a much needed directorship position and will bring forth a wide array of financial opportunities. His presence will help establish a solid footing that the Company can grow on.”
Grisaffi continued, “Last weekend, Rocky Mountain High Brands attended the CannaCon Convention in Seattle, Washington. We consider the event to be a huge success for the Company and this has brought us a step closer to the eventual introduction of I-502 friendly beverages in Washington State. Rocky Mountain High’s booth at CannaCon has attracted new potential business partners, distributors and retail accounts.  We look forward to attending CannaCon and other similar events nationwide in 2016.”
Washington State Retail Distributor:
Rocky Mountain High Society
Bret Cramm
5302 105 St NE
Marysville, Wa. 98270
Phone: (425) 346-2005

About Rocky Mountain High Brands:
 
We currently offer five wickedly delicious hemp-based beverages that are 100% legal and refreshing! Try one today!
Interested investors, our stock symbol is RMHB. 
For ordering information please visit: www.rockymountainhighbrands.com.

For Rocky Mountain High Distribution Contact:
Jerry Grisaffi: (214) 394-3865
jerry@rockymountainhighbrands.com

For USCBD information on CBD’s Contact:
Jerry Grisaffi (214) 394-3865
jerry@rockymountainhighbrands.com

Visit us at our Facebook page: https://www.facebook.com/rockymountainhighbrands?fref=nf 

Investors Hangout is the only authorized Investors blog page for Rocky Mountain High Brands, Inc.

NXT-ID Announces Purchase Order from WorldVentures for up to $15 Million for the New DreamTrips SmartCard to be Delivered in 2016


NXT-ID Announces Purchase Order from WorldVentures for up to $15 Million for the New DreamTrips SmartCard to be Delivered in 2016

NXT-ID Inc. (NASDAQ:NXTD) (“NXT-ID” or the “Company”), a company focused on the growing mobile commerce market, announces the first purchase order for a new SmartCard being developed for WorldVentures vacation club Members. On February 9, 2016, the Company announced that both companies signed off on the hardware specifications for the new product and that it was entering the manufacturing phase.

The DreamTrips™ card is a totally new product for NXT-ID and WorldVentures and will make travel, vacationing and even daily purchases simpler and more secure with a number of new and unique features to be announced prior to launch.

It is a next generation SmartCard that does not require a Wocket® and can operate as a stand-alone device. It can also sync to the DreamTrips Smartphone app for a connected user experience.

WorldVentures currently has approximately 500,000 DreamTrips Members, with as many as 80,000 new Members joining every month. The vision of WorldVentures’s executive team is to make the SmartCard available to every existing member and eventually, a general global consumer market.
The purchase order is for up to $15 million and is subject to WorldVentures acceptance of the prototype card now being manufactured. The purchase order calls for equal monthly deliveries with a value of $2.5 million a month from July to December 2016. With the exception of the order for the first $2.5 million, WorldVentures has the option to cancel, defer or increase monthly shipments with 90 days written notice on subsequent orders.

 About WorldVentures

WorldVentures Marketing, LLC is the leading international direct seller of vacation club memberships and helps people achieve more fun, freedom and fulfillment through their DreamTrips memberships which offer highly curated vacation, local entertainment, dining and event experiences enjoyed with the member community or individually. WorldVentures is a privately held company based in Plano, Texas, with active Representatives and Members in 28 countries.

For more information, please visit: http://www.worldventures.com.

About NXT- ID Inc. – Mobile Security for a Mobile World

NXT-ID, Inc.’s innovative MobileBio® solution mitigates consumer risks associated with mobile computing, m-commerce and smart OS-enabled devices. The company is focused on the growing m-commerce market, launching its innovative MobileBio® suite of solutions that secure consumers’ mobile platforms.

For more information, please visit: http://www.nxt-id.com

NXT-ID’ wholly owned subsidiary, 3D-ID LLC, is engaged in biometric identification and has 22 licensed patents in the field of 3D facial recognition http://3d-id.net/
Product images are available for media at: http://press.nxt-id.com

Rocky Mountain High Brands, Inc. (RMHB) To Attend ‘CannaCon’, The World’s Largest Cannabis Convention


Rocky Mountain High Brands, Inc. (RMHB) To Attend ‘CannaCon’, The World’s Largest Cannabis Convention

DALLAS, Feb. 16, 2016 (GLOBE NEWSWIRE) — Rocky Mountain High Brands, Inc. (RMHB) will be attending the world’s largest Marijuana Expo, ‘CannaCon’, February 18th-20th in Seattle, Washington. The three day expo in Seattle brings together buyers, exhibitors and consumers of the medical and recreational cannabis industry.
‘CannaCon’ is the world’s largest Cannabis business marketplace boasting over 300 vendors and 10,000+ attendees per show. ‘CannaCon’ is the Number One marketplace for Producers, Processors and Retailers.
For information on attending the 2016 show:  http://www.cannacon.org/.
Rocky Mountain High Brands will be at booth 1019 and will be offering T-Shirts, free samples of all five delicious flavors of hemp-infused beverages and discounted cases of product from our Washington State distributor, Rocky Mountain High Society.  Corporate representatives will also be in attendance to answer all questions regarding regional distribution opportunities.
“Where The Cannabis Industry does Business”
“Rocky Mountain High Brands is fired up to attend our first ‘CannaCon’ and it will no doubt help establish a more substantial footprint on the West Coast. We believe ‘CannaCon’ is a must attend event because all of the key players in the cannabis industry will be in attendance at this event. New distribution opportunities all across the nation will be generated from our presence at this and other similar events,” said Southern California Accounts Manager for Rocky Mountain High Brands, Venessa Adams.
Washington State Distributor:
Rocky Mountain High Society
5302 105 St NE
Marysville, WA 98270
Phone: (425) 346-2005
About Rocky Mountain High Brands:
We currently offer five wickedly delicious hemp-based beverages that are 100% legal and refreshing! Try one today!
Interested investors our stock symbol is RMHB.
For ordering information please visit: www.rockymountainhighbrands.com.
For Rocky Mountain High Distribution Contact:
Jerry Grisaffi: (214) 394-3865
jerry@rockymountainhighbrands.com

Visit us at our Facebook page: https://www.facebook.com/rockymountainhighbrands?fref=nf 

Investors Hangout is the only authorized Investors blog page for Totally Hemp Crazy.

Best Stocks to Buy for Around $1 (NXTD, MBII)


SilverCrest Metals (TSXV: $SIL) at Vancouver Resource Investment Conference 2016


SilverCrest Metals (TSXV: $SIL) at Vancouver Resource Investment Conference 2016

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SilverCrest is a Canadian precious metals exploration company headquartered in Vancouver, BC, that is focused on new discoveries, value-added acquisitions and targeting production in Mexico’s historic precious metal districts. The Company is led by a proven management team in all aspects of the precious metal mining sector, including experience and success in applying a responsible “phased approach” business model in taking projects from discovery, finance, on time and on budget construction, and production with subsequent increased value to shareholders. The Company was formed following the acquisition of SilverCrest Mines Inc. by First Majestic Silver Corp., which remains a shareholder in SilverCrest Metals Inc.

 SilverCrest Metals Inc. (TSXV: $SIL) at Vancouver Resource Investment Conference 2016

https://www.youtube.com/watch?v=gC95qAlGzBI

Las Chispas

The Las Chispas property is located approximately 180 kilometres northeast of Hermosillo, Sonora, Mexico. The community of Arizpe (estimated population 2,000) is located approximately 12 kilometres to the north of the property. The property consists of 17 concessions totalling to 1326.78 hectares.

In 1640, rich silver veins where discovered near Arizpe by soldiers under the command of Pedro de Perra.  The property did not receive any notable exploration or production until the late 1800s. From 1880 to 1930, several mines on the property had intermittent production. From public information, approximately 120 million ounces of silver and 200,000 ounces of gold were cumulatively produced from the property. Since 1930, no significant work has been completed on the property.

During the early 1980s, a local Mexican company reprocessed old waste and tailings dumps from Las Chispas. Processing was by vat leaching with no production records available.

In the first half of 2015, SilverCrest completed negotiations with local Mexican individuals and a Mexican company to acquire the property under several option to purchase agreements.  In 2014, prior to obtaining title to the property, SilverCrest incurred U.S.$149,599 in concession payments and other exploration expenditures. From January 1, 2015 to the date of the Application, SilverCrest incurred additional U.S.$69,146 in exploration expenditures, of which U.S.$50,000 was for concession payments.

Geologically, the Las Chispas property consists of a Late Cretaceous – Early Tertiary low sulfidation epithermal system. Host rocks are volcanic tuffs, rhyolites, agglomerates and rhyolite breccias. Andesite dykes are noted in underground workings sub-parallel to mineralized structures.
The Las Chispas Mine is known for its world-class silver mineral specimens including polybasite, stephanite, native silver and pyrargyrite. Specimens are on display in private collections and museums worldwide.

Mineralization occurs in 0.5 to 5 metre wide veins with adjacent stockwork and breccias trending northwest- southeast for 1 to 1.5 kilometres. Depth from surface of known mineralization is estimated at 300 metres. Main veins dip 55 to 85 degrees to the southwest. Fourteen epithermal veins have been previously defined on the property of which 3 have had notable production. The historical producing veins included Las Chispas, Guillermo Tell, and Babicanora.  From public information, the Las Chispas mill production between 1908 through 1911 was approximately 25,000 tonnes grading 35 gpt gold and 4,500 gpt silver totalling an estimated 25,000 ounces of gold and 3.2 million ounces of silver. Several kilometres of underground workings exist on the property and are partially accessible.

las_chispas_area_tn

Targets for modern exploration include drilling of near-surface (0 to 100 metres) vein extensions, depth (200 to 400 metres) extensions of historical producing areas, potential open pitable stockwork and breccia zones, and possibly reprocessing remaining waste and old tailings dumps.

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SilverCrest Metals plans to conduct general exploration including mapping, sampling, geochemical analysis for approximately Cdn.$25,000. Based on results of the general exploration, the Company is planning to conduct a drill program in Q1/16 to test known targets in the Las Chispas area. Payment obligations on the Las Chispas property during the next 18 months are property payments of U.S.$50,000 in 2015 and U.S.$105,000 in 2016.

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